Stem Cell Core
A growing repository of well-characterized iPSC ALS and control lines, including isogenic and reporter lines, generated by leading partners and stored and managed by Sampled.
Request Target ALS stem cell lines through The Jackson Laboratory or NINDS.
How we’re unlocking human models of ALS
Human iPSC-derived models are now critical tools for studying ALS and FTD biology and for testing candidate therapeutics. These models can uniquely capture human disease mechanisms that animal systems cannot. But generating and characterizing iPSC lines is resource-intensive and technically challenging for any single lab.
The Target ALS Stem Cell Core makes this technology broadly accessible to both academia and industry, with no reach-through on data or intellectual property.
What’s available through the Stem Cell Core?
Why Target ALS’s Stem Cell Core matters
Target ALS provides centralized access to stem cell lines, differentiation protocols, and genomic data. Well-characterized lines provide researchers confidence in the material they request, reduces time to get important experiments up and running, and allows for better science. All lines that can be used for research purposes by industry and academic organizations.
Researchers should check MTAs for lines where specific licenses may be needed to do research with the line.
The benefits of our Stem Cell Core:
- Cross-group validation of phenotype reproducibility.
- Integrated data through the Target ALS Data Engine.
- Accelerated discovery with tools designed for scalability, including high-throughput screening.
What's new in the Stem Cell Core
Target ALS is proud to announce a powerful new resource for ALS researchers: a collection of 28 standardized, well-characterized, and accessible fibroblast-derived induced pluripotent stem cell (iPSC) lines, available through the Stem Cell Core, with no strings attached.
