• Skip to primary navigation
  • Skip to main content
  • Skip to footer

Target ALS

A New York based ALS research organization that's leading the fight for a cure.

  • DONATE
  • About Us
    • Our Mission
    • Our Model
    • Our Impact
    • Our Founder
    • Our Team
    • Our Partners
  • For Scientists
    • Research Cores
      • Target ALS Data Engine
      • Longitudinal Biofluids Core
      • Human Postmortem Tissue Core
      • Stem Cell Core
      • Reagents Core
      • Animal Models Core
    • Funding Opportunities
    • Funded Projects
    • Annual Meeting
    • Science on Target Blog
  • Understanding ALS
    • About ALS
    • Understanding the Science
      • Glossary
      • FAQ
      • ALS 101
    • Voices of ALS
    • Video Library
  • Take Action
    • Support Geoff Greulich
    • The ALS Global Research Initiative (AGRI)
      • Global Natural History Study
      • Community Based Pop-Up Clinics
    • Ways to Give
    • Email Sign Up
    • Contact Us
    • Donate Now
  • News
    • Announcements
    • In the News
    • Newsletters & Reports

Glossary

Amyotrophic lateral sclerosis, more commonly known as ALS, is a progressive neurodegenerative disease in the central nervous system that impacts the brain and spinal cord, resulting in a loss of muscle control.

It is colloquially referred to as Lou Gehrig’s Disease, after the famous baseball player who battled it in the late 1930s, and does not yet have a cure. To better understand the language of ALS, the ALS Glossary below provides definitions for research terms commonly used by our Innovation Ecosystem and the extended ALS community.

ABCDEFGHIKLMNPRSTUWAll

human-induced pluripotent stem cell (hiPSC or iPSC) line

Pluripotent stem cells self-renew and can produce any cell or tissue the body needs. Human-induced pluripotent stem cells are generated directly from adult cells. These cell lines can be used to test or identify new therapies in a lab

hybridoma and hybridoma clones

A hybridoma is a hybrid cell formed by the fusion of two different types of cells–typically, a short-lived plasma cell capable of producing antibodies and an immortal cancer cell. The hybridoma produces continuous supply (clones) of a specific monoclonal antibody. These clones are tested to identify the ones that produce the desired antibody

hybridoma technology

Hybridoma technology is a method for producing large numbers of identical antibodies (monoclonal antibodies).

hyperreflexia

When muscle tendons respond in an exaggerated manner to a normal stimulus.

hyporeflexia

A weak or nonexistent muscle tendon response to normal stimuli.

Footer

Target ALS
  • Donate
  • Contact
  • Financial Reports
  • Call For Proposals
  • Annual Meeting
  • Privacy Policy
  • Credits

Follow Us

We are a 501(c)(3) public charity (EIN: 81-0756743), eligible to receive tax-deductible contributions that directly support our mission to break down barriers to ALS research to find effective treatments.

The Target ALS (TALS) website is intended for informational purposes only. Opinions expressed may not be that of TALS or its employees. For more information about our digital policies, click here.

© 2023 Target ALS Foundation, Inc.
Target ALS Foundation
244 Madison Avenue #1025
New York, NY 10016
(332) 333-4140
Steck Insights WordPress Consulting

Get our Summer Impact Report in your inbox – a special recap of our Annual Meeting and the progress we're making in ALS research.

Name(Required)
Interests(Required)
Mark the options that best describe your interest in ALS